Mauricio Tohen Selected Research

olanzapine-fluoxetine combination (Symbyax)

10/2014	Efficacy and safety of olanzapine/fluoxetine combination vs fluoxetine monotherapy following successful combination therapy of treatment-resistant major depressive disorder.
4/2010	Olanzapine/fluoxetine combination in patients with treatment-resistant depression: rapid onset of therapeutic response and its predictive value for subsequent overall response in a pooled analysis of 5 studies.
12/2007	Effect of comorbid anxiety on treatment response in bipolar depression.
9/2007	Onset of antidepressant effect of olanzapine and olanzapine/fluoxetine combination in bipolar depression.
5/2005	Analyses of treatment-emergent mania with olanzapine/fluoxetine combination in the treatment of bipolar depression.
1/2004	Effects of olanzapine alone and olanzapine/fluoxetine combination on health-related quality of life in patients with bipolar depression: secondary analyses of a double-blind, placebo-controlled, randomized clinical trial.

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Mauricio Tohen Research Topics

Disease

69	Bipolar Disorder (Manic Depressive Psychosis) 02/2022 - 01/2002
54	Mania (Manias) 01/2022 - 01/2002
25	Schizophrenia (Dementia Praecox) 01/2021 - 04/2002
25	Weight Gain 01/2020 - 01/2002
17	Psychotic Disorders (Schizoaffective Disorder) 01/2021 - 04/2002
6	Psychomotor Agitation (Akathisia) 01/2020 - 07/2003
6	Sleepiness 07/2009 - 01/2002
5	Substance-Related Disorders (Drug Abuse) 01/2022 - 08/2003
5	Body Weight (Weight, Body) 01/2020 - 12/2004
4	Nausea 01/2020 - 06/2002
4	Mood Disorders (Mood Disorder) 01/2017 - 01/2006
4	Tremor (Tremors) 07/2009 - 01/2002
3	Anxiety Disorders (Anxiety Disorder) 10/2019 - 02/2015
3	Prodromal Symptoms 10/2008 - 08/2003
2	Fatigue 01/2022 - 01/2020
2	Diabetes Mellitus 01/2020 - 06/2017
2	Treatment-Resistant Depressive Disorder 10/2014 - 04/2010
2	Major Depressive Disorder (Major Depressive Disorders) 10/2014 - 10/2014
2	Parkinsonian Disorders (Parkinsonism) 01/2006 - 08/2003
1	Metabolic Syndrome (Dysmetabolic Syndrome X) 02/2022
1	Bulimia (Binge Eating) 01/2020
1	Lipid Metabolism Disorders (Metabolism Disorders, Lipid) 06/2017
1	Pain (Aches) 01/2017
1	Hypothyroidism 01/2016
1	Obesity 10/2013
1	Overweight 12/2009
1	Sleep Initiation and Maintenance Disorders (Insomnia) 07/2009
1	Dyslipidemias (Dyslipidemia) 06/2009
1	Tardive Dyskinesia 06/2009
1	Disease Progression 05/2009
1	Diarrhea 11/2003

Drug/Important Bio-Agent (IBA)

66	Olanzapine (Zyprexa)FDA Link 11/2017 - 01/2002
37	LithiumIBA 02/2022 - 01/2002
36	Antipsychotic Agents (Antipsychotics)IBA 02/2022 - 12/2002
18	Quetiapine Fumarate (Seroquel)FDA Link 01/2022 - 07/2010
13	Valproic Acid (Depakote)FDA LinkGeneric 05/2012 - 01/2002
12	Antidepressive Agents (Antidepressants)IBA 01/2021 - 01/2003
12	Haloperidol (Haldol)FDA LinkGeneric 05/2012 - 08/2003
10	Pharmaceutical PreparationsIBA 04/2021 - 08/2003
7	Anticonvulsants (Antiepileptic Drugs)IBA 02/2022 - 12/2002
6	Risperidone (Risperdal Consta)FDA LinkGeneric 11/2015 - 11/2006
6	olanzapine-fluoxetine combination (Symbyax)FDA Link 10/2014 - 01/2004
5	CholesterolIBA 05/2013 - 10/2007
4	Triglycerides (Triacylglycerol)IBA 02/2022 - 02/2008
4	cariprazineIBA 01/2021 - 03/2015
4	Aripiprazole (Abilify)FDA Link 01/2021 - 11/2015
4	Fluoxetine (Prozac)FDA LinkGeneric 10/2014 - 11/2003
3	Glucose (Dextrose)FDA LinkGeneric 02/2022 - 10/2007
3	Carbamazepine (Tegretol)FDA LinkGeneric 05/2012 - 01/2004
2	mesoglycanIBA 01/2022 - 01/2020
2	CreatineIBA 01/2021 - 10/2020
2	Glutamine (L-Glutamine)FDA Link 01/2021 - 10/2020
2	Protons (Proton)IBA 01/2021 - 10/2020
2	Biomarkers (Surrogate Marker)IBA 01/2021 - 01/2018
2	Glutamic Acid (Glutamate)FDA Link 01/2021 - 10/2020
2	Drug CombinationsIBA 01/2020 - 01/2019
2	ProlactinIBA 11/2015 - 10/2007
2	BenzodiazepinesIBA 02/2015 - 06/2014
1	N-acetylaspartate (N-acetyl aspartate)IBA 01/2021
1	N-Methylaspartate (NMDA)IBA 01/2021
1	Inositol (Myoinositol)IBA 01/2021
1	Choline (Choline Chloride)IBA 01/2021
1	vasectrin II (VS II)IBA 10/2019
1	Anti-Anxiety Agents (Anxiolytics)IBA 01/2019
1	Lurasidone Hydrochloride FDA Link 06/2017
1	Acetaminophen (Paracetamol)FDA LinkGeneric 01/2017
1	Non-Steroidal Anti-Inflammatory Agents (NSAIDs)IBA 01/2017
1	Analgesics (Analgesic Drugs)IBA 01/2017
1	Ketamine FDA LinkGeneric 05/2016
1	APTIBA 01/2016
1	Oxcarbazepine (Trileptal)FDA LinkGeneric 01/2016
1	Dopamine (Intropin)FDA LinkGeneric 11/2015
1	HDL LipoproteinsIBA 03/2015
1	4-methyl-2,3-secocholestane-2,3-diolIBA 03/2013
1	ORALIT (ORS)IBA 02/2011
1	Biological ProductsIBA 02/2011
1	lipoarabinomannan (LAM)IBA 07/2009
1	SmokeIBA 09/2008
1	Lithium Carbonate (Eskalith)FDA LinkGeneric 01/2008
1	Uric Acid (Urate)IBA 10/2007
1	EnzymesIBA 10/2007
1	Lamotrigine (Lamictal)FDA LinkGeneric 07/2006
1	Cholinergic Antagonists (Anticholinergics)IBA 01/2006
1	Perphenazine (Trilafon)FDA LinkGeneric 01/2004
1	Alanine Transaminase (SGPT)IBA 07/2003
1	Temazepam (Nocturne)FDA LinkGeneric 04/2002

Therapy/Procedure

13	Therapeutics 01/2018 - 01/2002
8	Drug Therapy (Chemotherapy) 01/2022 - 12/2002
3	Polypharmacy 01/2020 - 01/2019
2	Secondary Prevention 10/2014 - 03/2006
1	Aftercare (After-Treatment) 12/2018
1	Duration of Therapy 10/2013